Xtreme NO
  • Editor Rating
  • Rated 2.5 stars
$48.00 to $149.85
  • 50%

  • Xtreme NO
  • Reviewed by:
  • Published on:
  • Last modified: May 3, 2016
  • Overall
    Editor: 46%
  • Effectiveness
    Editor: 46%
  • Speed of Results
    Editor: 46%
  • Sustaining Results
    Editor: 46%
  • Safety
    Editor: 46%
  • Value
    Editor: 46%

What Is Xtreme NO?

Xtreme NO is a nitric oxide supplement that is designed to carry you through even the most grueling and challenging of workouts. Unlike some NO supplements, which only contain one (or maybe two) ingredients, this product is specially formulated with both nitric-oxide boosting compounds and electrolyte support, making it uniquely complete. This supplement’s extended release formula makes it especially effective because you get the same benefits throughout your workout – not just at the beginning.

But why even take a nitric oxide booster in the first place? Many people take a pre-workout and consider that enough. But the main purpose of pre-workout is to energize you and prepare you to power through a workout. Nitric oxide, on the other hand, is a compound that can enhance your workout and recovery by boosting blood flow to muscles (without simultaneously boosting blood pressure). When you take nitric oxide boosters, your muscles remain well-oxygenated and well-nourished. This benefits both cardio and strength training pursuits. In short, Xtreme NO is a nitric oxide boosters with enough extra that it merits a second look.



Xtreme NO is made by a manufacturer that only makes this particular supplement. This may seem strange at first, seeing that some supplement ad campaigns are built solely on the fact that they are made by a major manufacturer. However, there are some surprising benefits to getting a supplement from a one-supplement manufacturer. For instance, think about the last time you called a major supplement supplier to ask about a specific supplement.

Chances are, the sales representative you spoke with didn’t know all there as to be known about the specific supplement you called about. Knowing each supplement in depth when you work for a company that makes hundreds of supplements is virtually impossible. On the other hand, when you call the Xtreme NO customer support line, you will speak with someone who only needs to know one supplement: this one. This benefits you, the customer, because you can learn from the customer service representatives’ in-depth knowledge as well.


How Xtreme NO Works?

Xtreme NO works much like many other nitric oxide boosters, but with a twist. First, it works to improve athletic performance by increasing blood flow, supporting muscles during a workout, supporting recovery, and boosting endurance. Both L-arginine and L-citrulline support increased blood flow along with increased blood vessel diameter. Lifting weights causes a temporary rise in blood pressure, and any additional rise caused by a supplement can be dangerous. This increased oxygenation is important because, as we all know, oxygen and nutrients are carried to muscle tissue in the blood.

Whether you’re trying to do one more rep or run another mile, tissue oxygenation is important. This, along with the ability of nitric oxide to help clear muscle waste, helps to delay the onset of fatigue. Muscle fatigue (and eventually muscle failure) happens when lactic acid builds up in the muscle tissue – this is the “burning” sensation you feel in a workout.

One of the more overlooked benefits of a nitric oxide supplement is the fact that taking one can actually aid in muscle recovery. Particularly in an extended-release compound like this one, muscles continue to be well-oxygenated and well-nourished for hours. This means that the recovery meal you have post-workout is put to good use repairing muscle tissue.However, this supplement includes electrolytes and an ingredient that is instrumental in energy production as well. Together, these additional benefits help to pump you up for a workout and keep you energized throughout – not just at the beginning.


Ingredients of Xtreme NO

Though it has more ingredients than your average NO booster, Xtreme NO still has relatively few ingredients. They are listed below, along with a little bit about each one:

L-arginine hydrochloride

This is a simple salt form of L-arginine. You’ll notice that there are three forms of L-arginine included in this product. While that may seem redundant, this is actually a key part of the extended release formula at work. While this ingredient and the two below it contain L-arginine, each sees this ingredient bonded to a different thing.

Because different molecules are broken down at different rates, this ensures that the body has a gradually-released stream of L-arginine available. This is important – if you’ve ever felt like you hit a wall mid-workout, your pre-workout or nitric oxide supplement wearing off most likely played a role.

But why is L-arginine even important? For many years, the fitness community has known that this compound has many benefits. But nobody knew exactly why it appeared to be so helpful in being able to boost both strength and endurance, as well as support recovery. In 1998, a groundbreaking study revealed the “why” – this supplement increased blood flow to muscles while simultaneously widening the walls of blood vessels. This meant that muscles received more nutrients and more oxygen, but that blood pressure was not increased. This study won the Nobel Prize in Medicine, adding further support to the efficacy of L-arginine in boosting nitric oxide production.

L-arginine alpha ketoglutarate

This unique molecule combines L-arginine (whose benefits are discussed above), with alpha ketoglutarate. There is significantly less research that has been done on alpha ketoglutarate, but preliminary research suggests that this molecule can combine with ammonia that builds up in the body (especially during exercise), and that it can reduce ammonia toxicity. Thus far, though, that research has been conducted on hemodialysis patients, and it is unclear if the same benefits hold true for those not on hemodialysis.

L-Arginine ketoisocaproate

This is yet another form of L-arginine, and this time it’s combined with ketoisocaproate. Ketoisocaproate has been rumored to support production of adenosine triphosphate, or ATP, which is what provides energy on the cellular levels. More research is needed to verify this claim.


This amino acid, like L-arginine, supports blood flow to muscles. It is another amino that provides the building blocks needed to form nitric oxide, and the mechanisms of the two are similar. However, some research has shown that L-citrulline is an even better nitric oxide booster than L-arginine.

This study found that, in people who had taken either L-arginine or L-citrulline, arginine levels in the blood remained higher. This indicated that the body does not use arginine as readily as it does citrulline. In addition, arginine is also more readily destroyed in the body before it can be used to help oxygenate muscle tissue.

Dipotassium phosphate

This is a salt form of the electrolyte potassium. Electrolyte balance is important for everyone, but it’s especially important in exercise, when your electrolytes are much more readily depleted. Potassium and sodium are two major electrolytes, but potassium tends to be more scarce in the diet, which is why it is included here. Too little electrolytes can mean fatigue, dizziness, and other symptoms you don’t want when you’re at the gym.

Dicalcium phosphate

This is a salt form of calcium, which is important in any supplementation program. In any sort of exercise program, it’s important to make sure you’re getting enough calcium – it supports bones and other tissues. You may not know that calcium is ital for muscle function, heart rhythm, and a host of other functions closely related to exercise as well. An added benefit is that you get great muscle pumps: that full post-workout feeling you get in a muscle group you’ve just worked.

Nicotinamide adenine dinucleotide

This ingredient, abbreviated NADH, is important for energy production in the body. It has even been used to help treat chronic fatigue syndrome. NADH helps to improve focus and drive, which is important if you want to do your best in all your workouts. It’s a great alternative for people who can’t tolerate caffeine, yohimbine, or other stimulants.



There are a host of advantages to taking Xtreme NO as your nitric oxide booster. A major advantage is the fact that this is an extended-release supplement. This benefit becomes more important as you extend the time you spend working out. Particularly if you’re someone who does cardio and then strength with no break, supplementing with an extended-release NO booster can help to dramatically improve your workout. The extended-release feature also means you’ll have better muscle recovery support.

Another advantage is the inclusion of NADH – this ingredient, seeing as it is used to treat chronic fatigue symptoms – can help to delay fatigue onset and energize you without the jitters that yohimbine and other stimulants have sometimes been known to cause. Additionally, potassium and calcium help to round out this supplement as a metabolic support for pre, during, and post-exercise.



This supplement has not received any certificates of its own as of yet. However, the fact that it is a relatively new formula may have something to do with this. It is worth noting, though, that it received a very favorable review on SupplementCritique.com, a site in which employees will actually test a supplement for a few months, research the ingredients, and write a detailed impression of the supplement.

And while Xtreme NO itself did not win a Nobel Prize, the research that went into it (specifically, the research surrounding L-arginine) won the Nobel Prize in Medicine. Considering the fact that some supplements are backed by little to no research, the inclusion of this ingredient says something favorable about this product.



Sometimes, before you buy a supplement, it can help to hear from those who have tried it and loved it. Here are some words from those who have used this product:

Jacob, 31, Charlottesville, VA:

Once you hit 30 you sort of hit a wall. I’ve been taking pre-workout for years, but it wasn’t cutting it. So I talked to my gym buddies, and it turned out my issue was that it wasn’t extended release. And that made sense – I would get so pumped for a workout, and then 30 minutes in I’d just die. It was disappointing. So I started looking for extended-release nitric oxide boosters and found this one. It works great! I do take it with caffeine though, just to give me an extra boost.

Steven, 44, South Bend, IN:

I actually saw this product as an ad online and just randomly clicked it. I was surprised by how low the price was, and I loved that it wasn’t an auto-ship scam. So I bought the one-bottle deal. It’s more per bottle that way, but I had to be sure I liked it. It took me about a week to get into the groove of it, but then I saw how great this stuff is. Really impressive. I’ve gotten three new PRs in the month I’ve been taking it!


Awards & Media Coverage

On its own, this supplement has not garnered much media coverage. However, as mentioned above, it has been favorably reviewed on Supplement Critique, which is a large supplement-review website. Additionally, the fact that it’s supported by Nobel Prize-winning research supports manufacturer claims that this is, in fact, an NO booster that really works.

However, it is likely that this supplement may receive more media coverage as more research is conducted on L-citrulline. This is because merging research suggests that L-citrulline may be a better NO booster than L-arginine.


Money-back Guarantee

The makers of Xtreme NO stand behind their product. Thus, they offer a 100 percent satisfaction guarantee. If you are dissatisfied in any way with the product, simply send back the unused portion and receive a full refund. This company’s return policy is more generous than most – you have 90 days to return any unused product for a purchase price refund. Many other companies only allow 30 days for you to make this decision. There are no questions asked. However, please note that you will be responsible for return shipping. You also may need to arrange for a return authorization. This is when you call the company ahead of time and pre-authorize a return shipping.



Shipping is free on all orders shipped to the contiguous United States. All orders are shipped via USPS First Class Mail, and they all come with tracking options so you can see where your package is at any given time. US orders will arrive in seven to 14 days, while international orders may take 10 to 21 days. In case you’re concerned about people knowing that you supplement, rest assured: packaging is discreet and will not indicate what kind of product is on the inside.


Customer Support

Xtreme NO customer support specialists are experts on their product, and they are committed to helping you make the best decisions for your health and fitness goals as possible, whether or not those decisions involve their product or not. The customer support team strives to make itself available through a variety of different venues. You can contact them by phone, by e-mail, by web form, or by traditional mail. Since customer service representatives are extremely knowledgeable about this product, they are prepared to answer virtually any question you may have about this product.


Safe & Secure Checkout

When you order online from this company, you can rest assured that all information is kept safe and secure. It used to be that people were extremely concerned about ordering online because of the horror stories of people stealing information. While that may happen on some sites, Xtreme NO uses state-of-the-art encryption techniques to protect your information from hackers. The website conforms that the security of this checkout is verified by multiple independent agencies. In addition, this company will not sell, lease, give away, or otherwise share any of your information – it’s safe.


Xtreme NO Pricing

While there are rumors floating online – and the website mentions a “trial” when describing the money-back guarantee – there is actually free trial option for this product. However, pricing is reasonable and is based on the volume you order. This product manufacturer offers three packages. The first is the “Sampler Package” which is one bottle (a one-month supply) for $48. The next is the “Tier 2 Package,” which is two bottles plus a free additional one for $99.90 total. And the third and best-selling package is the “5 Month Special Offer Plan,” which is three bottles plus two free for $149.85.


There are many pros to taking Xtreme NO. These include:

  • This product includes L-citrulline, which some research suggests is better at boosting nitric oxide than L-arginine.
  • It contains electrolyte support to support general well-being and workout duration.
  • The extended-release formula means you have support before, during, and even after your workouts.


As with any supplement, this one has some cons. They include the following:

  • For those who plan to use this as a pre-workout supplement, the lack of caffeine may be inconvenient.
  • Though it includes potassium, it does not include a full electrolyte profile.

Xtreme NO

Summary: Xtreme NO is a nitric oxide booster that has some extras that set it apart. This extended release formula is designed to support muscle growth and healthy metabolism before, during, and after all workouts. L-arginine and L-citrulline are included to help increase oxygenation and nourishment of muscles during and after your workout to support performance an recovery. Electrolytes and vital components of energy production are included to keep you focused and performing your best. This is a product that can support cardio and strength training alike, as well as speed muscle repair to get you ripped faster than ever. Plus, it’s backed by Nobel Prize winning research.

$48.00 to $149.85
RatingRated 2.5 stars

Allen Hicks is a professional bodybuilding coach and author. By using his experience, knowledge and understanding of all the intricacies regarding the fitness and bodybuilding industry, this websites delivers detailed reviews for every new supplement on the market. As an author, he may receive some small compensation for some of them, however we guarantee the neutrality regarding the evaluating of each of the products and the factuality of the information.